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Biol Trace Elem Res 195:499505 [DOI] [PubMed] [Google Scholar] Friedman B, Cronstein B (2019) Methotrexate mechanism in treatment of rheumatoid arthritis

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Oxidative stress in chronic kidney diseases is characterized by several distinct pathways: oxidative stress mediated by ROS ( OH), nitrosative stress mediated by RNS (ONOO , NO 2 ), chlorinated stress mediated by chlorinated species (HOCl), and carbonyl stress (Advanced glycation end products, AGEs) (Ling and Kuo 2018)

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